Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease
نویسندگان
چکیده
منابع مشابه
Chimeric analysis of T (Brachyury) gene function.
To investigate T(Brachyury) gene function, a chimeric analysis of midgestation (9.5-11.5 days post coitum) embryos has been performed. Embryonic stem (ES) cell lines homozygous or heterozygous for the T gene have been introduced into wild-type host embryos by blastocyst injection, and the resulting chimeras scored for morphological abnormality and extent of colonization by T/T cells. As observe...
متن کاملThe human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy.
PURPOSE Identification of tumor antigens is essential in advancing immune-based therapeutic interventions in cancer. Particularly attractive targets are those molecules that are selectively expressed by malignant cells and that are also essential for tumor progression. EXPERIMENTAL DESIGN AND RESULTS We have used a computer-based differential display analysis tool for mining of expressed sequ...
متن کاملno tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.
The mouse T (Brachyury) gene is required for normal mesoderm development and the extension of the body axis. Recently, two mutant alleles of a zebrafish gene, no tail (ntl), have been isolated (Halpern, M. E., Ho., R. K., Walker, C. and Kimmel, C. B. (1993) Cell 75, 99-111). ntl mutant embryos resemble mouse T/T mutant embryos in that they lack a differentiated notochord and the caudal region o...
متن کاملGenetic mapping of the human homologue (T) of mouse T(Brachyury) and a search for allele association between human T and spina bifida.
We describe a genetic analysis of the human homologue (T) of the mouse T (Brachyury) gene; human T was recently cloned in our laboratory. The protein product of the T gene is a transcription factor crucial in vertebrates for the formation of normal mesoderm. T mutant Brachyury mice die in midgestation with severe defects in posterior mesodermal tissues; heterozygous mice are viable but have pos...
متن کاملMouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.
The mouse Brachyury the Second (T2) gene is 15 kb away from classical Brachyury (T). A mutation in T2 disrupts notochord development, pointing to the existence of a second T/t complex gene involved in axis development. T2 encodes a novel protein that is disrupted by an insertion in T2(Bob) mice. Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop co...
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ژورنال
عنوان ژورنال: Mammalian Genome
سال: 1997
ISSN: 0938-8990,1432-1777
DOI: 10.1007/s003359900581